National Geographic News
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The sperm in this file photo were likely created in a fraction of a second.

Photograph by Manfred Kage, Photo Library  

Christine Dell'Amore

National Geographic News

Published March 18, 2010

Attention, men: In the last second your bodies each produced at least 1,500 sperm cells. Now researchers have unlocked just how this seminal feat is possible.

For the past 40 years scientists have thought stem cells in the testicles—also called germline stem cells—become sperm only through a simple, two-step process.

Not so. Germline stem cells, it seems, can become sperm in several different ways, according to new experiments with mice. (Explore an interactive of the human body.)

"What we're saying is there isn't a strict linear progression from a stem cell to a [sperm] cell," said study co-author Robert Braun, associate director at the Jackson Laboratory in Bar Harbor, Maine. "Sometimes the stem cells go through several cell divisions to get there, sometimes they don't."

What's more, the researchers found that a cell that's partway to becoming a sperm cell can revert back to being a germline stem cell—previously thought impossible.

For the new study, scientists genetically engineered mice so that their germline stem cells appeared fluorescent, allowing the team to watch the cells' development. (For more on this technique, see "Chemistry Nobel Prize Awarded for Glowing Protein Work.")

The scientists also "labeled" specific cells within the mouse germline stem cells a certain color and observed what happened to them over a period of several days. (Related: "'Brainbows' Illuminate the Mind's Wiring.")

The research also revealed that sperm develop from a smaller subset of specialized germline stem cells in the testes than previously thought.

Sperm Live Fast, Die Young

Since sperm are short-lived, they must constantly be replenished, Braun noted—hence that 1,500-per-second production rate.

"In addition, fertiization is surprisingly inefficent," he said. "There has to be a large initial payload [for those] few cells to make it to the final destination"—the woman's egg.

But continuously pumping out a stream of sperm cells from puberty to old age requires a man's body to maintain a very delicate germ cell balance.

For instance, if germline stem cells stay stem cells for a long time and don't change into sperm cells, a man may be at risk of getting testicular cancer. But if germline stem cells too often develop into sperm, a man may become infertile.

Sperm Research May Lead to Male Birth Control

Unlocking such mysteries of sperm development could someday lead to infertility treatments or even the elusive male birth control pill, said Braun, whose research appears tomorrow in the journal Science. (Related: "New Sex Hormone Found—May Lead to Male Birth Control?")

For instance, scientists may learn how to keep germline stem cells from becoming sperm.

"The more we learn about the normal behavior of cells," Braun said, "the more we know how to manipulate them."

3 comments
rex strong
rex strong

this is also the technology that might bring up interest in cellular technology in the case of living forever, if we learn what science and cell systems manipulate cell birth and death then we may be able too unlock that science in our current state or forms and manipulate it with something like a bionic womb and a hefty series of drugs composing different sequences on a cellular level, we know the egg keeps the sperm alive and creates a new manifesto of the sperm into a new fetus state but is it only the sperm that the egg recognizes and can we copy or adapt that science or manipulate it too our current states or form as adults. From what I know about cellutosis if its true or not we have a 7 year cycle which where the body periodically  is completely renewed, so there's that new function of the body too consider and how and also the rustic oxygen system which is is said too explain how oxygen is killing us but keeping us alive at the same time...

Dusty Ó Mórdha
Dusty Ó Mórdha

Actually there is a pretty large interest in male birth control, especially with married men who have the option of a vasectomy or a potentially reversible alternative (in the event they change their mind.. get remarried..).  
There are currently at least two forms of male birth control that I know of being tested.  Vasalgel is in clinical trials and is a polymer gel injected into the vas deferens, rather than than having the vasectomy.  It completely blocks passage of sperm (with an unbelievable 100% success rate last I read) and the gel can be removed by simply adding a biocompatible reagent that dissolves the gel.  Not sure on the success of reversal to be honest, but knowing how this pathway works, I'm sure it's basically 100%.  
The other treatment is also non-hormonal, and involves consuming a molecule that basically makes it so your sperm lack an essential protein involved in conception, but they are otherwise no different.  

Personally, I would take either of these.  Female contraception isn't guaranteed, even less so are the consistency at which they are taken.  Why not double up on contraception if it's affordable? 

Sean Schattner
Sean Schattner

I don't believe men are looking for a birth control pill to be completely honest... And as far as I know most men would rather be fertile considering the many who have erectile disfunctions and so forth. If there was something new that we could do with our sperm then that would be awesome though! Otherwise its just a cool fact to know.

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