Neanderthal Genome "First Draft" Unveiled

February 12, 2009

A "first draft" of the Neanderthal genome announced today adds to evidence that the extinct human species was lactose intolerant and could have shared some basic language capabilities with modern humans.

The human and Neanderthal family trees split off from each other around 450,000 years ago, after which there was little or no mixing between the two species.

Neanderthals vanished about 30,000 years ago, leaving modern humans to inherit the Earth. Why humans ended up being more successful has long been a topic of debate.

The newly completed sequence shows that humans and Neanderthals have genomes that are 99.5 percent the same.

By comparing the human and Neanderthal genomes with that of our closest living relative, the chimpanzee, researchers hope to tell which genes changed very recently, giving modern humans an edge.

"Studying the Neanderthal genome will tell us what makes modern humans really modern, and really human," said project collaborator Jean-Jacques Hublin, of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany.

Reading the Genome

An animal's genes are made up of base pairs, the "letters" of the genetic alphabet. Genes give organisms their physical traits, from hair color to body shape. By contrast, a genome is the full set of genes that gives rise to a particular species.

Sequencing the more than 3.7 billion base pairs in the Neanderthal genome took about four years. So far the team has read only about 60 percent of the genes.

The initial results, announced today at a press conference at the Max Planck Institute, show intriguing contrasts between us and our ancient cousins.

For example, the research supports previous studies of Neanderthal DNA that show we share the same version of a "language gene" called FOXP2, noted team leader Svante Pääbo, also of the Max Planck Institute.

This gene is involved in linguistic development, suggesting that Neanderthals could talk.

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