Dinosaur Soft Tissue Sequenced; Similar to Chicken Proteins

Scott Norris
for National Geographic News
April 12, 2007

Ancient collagen—the main protein component of bone—has been extracted from the remains of a 68-million-year-old Tyrannosaurus rex, according to two new reports.

The new studies provide strong support for the hotly debated claims that organic material previously extracted from the T. rex's leg bone is original dinosaur soft tissue that somehow escaped fossilization.

Now, for the first time, scientists have obtained partial protein sequences from the soft tissue remains.

"The sequences are clearly from T. rex," said John Asara of Harvard Medical School in Cambridge, Massachusetts, who led one of the studies.

In addition, both studies found similarities between the dino sample and the bone collagen of chickens, providing molecular support for the hypothesis that modern birds are descended from dinosaurs.

Until now the dino-bird connection has been entirely based on physical similarities in fossils' body structures (related: "Earliest Bird Had Feet Like Dinosaur, Fossil Shows" [December 1, 2005]).

In a related study, a team led by Mary Higby Schweitzer of North Carolina State University conducted tests that also revealed the presence of collagen in the T. rex remains.

In one experiment, antibodies that normally react in the presence of chicken collagen reacted strongly to the dinosaur protein, suggesting a similar molecular identity.

Multiple Tests

For the protein sequencing study, Asara's team isolated seven fragmentary chains of amino acids—the building blocks of proteins—from the T. rex specimen.

The results are by far the oldest such data ever recovered. Previously, the earliest protein sequence data came from a 300,000-year-old mammoth specimen.

Asara's team extracted the amino acids using a highly refined version of the analytical technique known as mass spectrometry.

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