Woolly Mammoth DNA Reveals Elephant Family Tree

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In this week's Science another team published the results of its own woolly mammoth genetic study, which decoded the longest-ever sequence of the animal's genome.

The team, led by biologist Ross D. E. MacPhee of the American Museum of Natural History, compiled some 13 million DNA base pairs—a small but significant part of the animal's complete genome.

"This new genomic sequence of the woolly mammoth is orders of magnitude better than any previous result," MacPhee said, "and it raises the possibility that scientists could sequence the whole mammoth genome in the near future, possibly within the next year."

The human genome was decoded only six years ago, and no complete genomes have yet been sequenced for extinct animals.

The results raise the specter of cloning or recreating the extinct animals from frozen bits of their ancient DNA, perhaps to populate some type of real-life "Jurassic Park."

MacPhee explained that such an event, if possible, remains far down the road.

"While we can now retrieve the entire genome of the woolly mammoth, that does not mean we can put together the genome … with all the functional apparatus needed for life. We can't even do that with modern DNA," he said.

Though the mammoth genome might not bring the extinct animals back to life, it could help scientists learn why they vanished.

Comparing ancient DNA with the genomes of living animals might help scientists learn what factors cause new species to arise while others perish.

Permafrost Museum?

Retrieving mammoth bone, even well-preserved bone that can yield DNA, is not as difficult as might be supposed, scientists say.

The beasts roamed Siberia until about 10,000 years ago, when scientists believe they became extinct due to warming weather, human hunters, disease, or some combination of these factors.

There are believed to be millions of mammoths buried in Siberia's permafrost. Only about a hundred specimens have been uncovered in the sparsely populated countryside—but some of them have been remarkably well preserved.

"There are hundreds or perhaps even thousands of samples that contain DNA," Hofreiter said.

Geneticists may now be able to put those samples to better use.

"Using the knowledge we've gained, this technology can be used quite widely on ancient DNA to resolve the [evolutionary histories] of both extinct and extant species," Hofreiter said.

"We may even be able to conduct population studies using ancient mitochondrial DNA. There will be some things to resolve and maybe some interesting surprises as well."

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