The researchers selected five key waypoints as the crossroads of ancient human migrations: Cairo, Egypt; Istanbul, Turkey; Cambodia; and the Alaskan and Russian coasts along the Bering Strait.
"We tried to figure out what kind of picture of human evolutionary history would explain the high [genetic] correlation that we observed," said Noah Rosenberg, a University of Michigan geneticist and study co-author.
Out of Africa
The team says their research kept pointing back to a single place of human originAfrica.
"When we searched over 4,000 points around the world, we found that no point outside of Africa had as high a fit as any point inside of Africa," Rosenberg said. "So this seems to support an 'Out of Africa' historical model for human evolution."
Genetic diversity is highest, and thus oldest, in Africa. This fact has led many geneticists to point to the continent as the birthplace of humankind.
Genetic data suggest what scientists call a serial founder effect. The theory holds that each group of migrating humans begat a later, smaller subgroup that subsequently continued humankind's journey around the globe.
Each time a subset migrated onward, genetic diversity narrowed. As a result, naturally occurring random genetic variationsalso known as genetic driftincreasingly influenced the genetic makeup of gradually more homogenous populations.
Genetic diversity was found to be lowest in the Americas, which are widely believed to be the last continents settled by humans.
The team concludes that perhaps 75 percent of humankind's modern genetic variation is the result of random genetic drift.
The researchers suggest that only 25 percent of our genetic diversity stems from the evolutionary process of natural selectionthough such a number is still significant.
"Undoubtedly natural selection has played an important role in altering our genome during this migration out of Africa," Ramachandran said. "But it is kind of new to think that genetic drift might have been responsible for this much of human genetic variation."
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